Negatively-charged helices in the gas phase.
نویسندگان
چکیده
A polyalanine-based peptide which forms a stable, negatively-charged α-helix in the gas phase is reported. Addition of an N-terminal acidic residue forms a stabilizing hydrogen bond network and an electrostatic interaction with the helical dipole. Formation of this secondary structure was demonstrated using ion mobility-mass spectrometry and molecular modelling techniques.
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عنوان ژورنال:
- Chemical communications
دوره 50 64 شماره
صفحات -
تاریخ انتشار 2014